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The VExUS Score : Fundamentals & Pathophysiology
Definition
VExUS (Venous Excess UltraSound) is a multiparametric ultrasound score designed to quantify systemic congestion beyond simple Inferior Vena Cava (IVC) diameter measurement.
Mechanism
It's thought that when maximum venous capacitance is reached, venous pressure rises sharply. This pressure transmits cardiac cycle waves backward into the splanchnic veins to the hepatic, portal, and renal veins.
Clinical Significance
- Cardiac Surgery: Historically the primary field of application for predicting post-operative Acute Kidney Injury (AKI).
- General Critical Care: Now extended to ICU patients and those with chronic heart failure to guide fluid removal.
- The Surgical Kidney: Recent data shows a strong linear correlation between Intra-Abdominal Pressure (IAP) and the Renal Resistive Index (RRI), where RRI = 0.55 + (0.015 * IAP).
Pitfalls & Limitations
Severe TR: Severe Tricuspid Regurgitation can mimic severe congestion on Hepatic Vein doppler (S-reversal) even if the overall volume status is not the primary cause.
Both the hepatic vein and the renal vein can be affected, the only VExUS parameter that remains reliable is the portal vein in the non-cirrhotic patient.
The portal system is separated from the right heart by hepatic sinusoids, which prevent the direct transmission of cardiac waves. Therefore, portal pulsatility often better reflects true congestive states and is a superior predictor of diuretic responsiveness
Interactive Clinical Cases
Click below to load specific hemodynamic profiles into the simulator: